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Product Name
PRDX1 antibody
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Description
PRDX1 Rabbit Polyclonal antibody. Positive IF detected in HepG2. Positive WB detected in HeLa cells. Observed molecular weight by Western-blot: 23kd
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Tested applications
ELISA, WB, IF
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
PRDX1 antibody; TDPX2 antibody; PAGB antibody; PRXI antibody; NKEF A antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_002574). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:1000-1:10000
IF: 1:10-1:100
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:114176(PRDX1 antibody) at dilution of 1:500
Immunofluorescent analysis of HepG2 cells, using PRDX1 antibody Catalog No:114176 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
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Background
PRDX1, also named as PAGA, PAGB, TDPX2, PAG and NKEF-A, belongs to the ahpC/TSA family. It is involved in redox regulation of the cell. PRDX1 reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. PRDX1 plays an important role in eliminating peroxides generated during metabolism. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. The antibody is specific to PRDX1.
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