PRCP antibody

PRCP antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PRCP Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, human liver tissue. Positive IP detected in L02 cells. Positive IHC detected in human lung cancer tissue. Observed molecular weight by Western-blot: 56 kDa

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

Angiotensinase C antibody; HUMPCP antibody; Lysosomal carboxypeptidase C antibody; PCP antibody; PRCP antibody; Proline carboxypeptidase antibody; Prolylcarboxypeptidase antibody

Rabbit IgG

This antibody was obtained by immunization of PRCP recombinant protein (Accession Number: NM_005040). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PRCP(Lysosomal Pro-X carboxypeptidase) is also named as PCP and belongs to the peptidase S28 family. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. PRCP is both a PK activator and an angiotensin II inactivator indicates another previously unappreciated interaction between the plasma kallikrein/kinin and the renin-angiotensin systems(PMID:11830581).Some previous gelfiltration and dynamic-light scattering results suggested that PRCP is a dimer in solution(PMID:20540760). The full length protein has a signal peptide, a propeptide and six glycosylation sites and can exsit as 65 kDa modified protein.

• Lenain C, Gusyatiner O, Douma S, van den Broek B, Peeper DS. Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence. Carcinogenesis. 36(11):1263-74. 2015.