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PR antibody

Cat.#: 107481

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Special Price 239.0 USD

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Product Information

  • Product Name
    PR antibody
  • Documents
  • Description
    PR Mouse Monoclonal antibody. Positive IHC detected in human breast cancer tissue.
  • Tested applications
    ELISA, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    NR3C3 antibody; PGR antibody; progesterone receptor antibody
  • Immunogen
    Human PR Recombinant protein (His tag)
  • Isotype
    Mouse IgG1
  • Preparation
    This antibody was obtained by immunization of PR recombinant protein (Accession Number: NM_000926). Purification method: Protein G purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    IHC: 1:50-1:500

  • Validations

    Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using (PR Antibody) at dilution of 1:3200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using (PR Antibody) at dilution of 1:3200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using (PR Antibody) at dilution of 1:3200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using (PR Antibody) at dilution of 1:3200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

  • Background
    PGR, also named as NR3C3 and PR, belongs to the nuclear hormone receptor family and NR3 subfamily. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. The ER and PR status has been used as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"