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Product Name
PPYR1 antibody
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Description
PPYR1 Rabbit Polyclonal antibody. Positive IHC detected in human small intestine tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
Neuropeptide Y receptor type 4 antibody; PP1 antibody; PPYR1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PPYR1 recombinant protein (Accession Number: XM_011549374). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemistry of paraffin-embedded human small intestine tissue slide using Catalog No:114161(PPYR1 Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human small intestine tissue slide using Catalog No:114161(PPYR1 Antibody) at dilution of 1:50 (under 40x lens)
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Background
PPYR1 (pancreatic polypeptide receptor 1), also known as NPY4R, is a member of the G-protein coupled receptor 1 family. PPYR1 is a receptor for the PP-fold peptides (pancreatic polypeptide, peptide YY, and neuropeptide Y) and pancreatic polypeptide is the preferred ligand (PMID: 12626767). It may be regulating central nervous system, cardiovascular and gastrointestinal function. It has been reported that PPYR1 gene is a key regulator of energy homeostasis (PMID: 12000791). PPYR1 gene copy number gain has been associated with lower body mass index (BMI) (PMID: 19229253).
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