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Product Name
PPT1 antibody
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Description
PPT1 Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CLN1 antibody; INCL antibody; Palmitoyl protein hydrolase 1 antibody; PPT antibody; PPT 1 antibody; PPT1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PPT1 recombinant protein (Accession Number: NM_000310). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human kidney using Catalog No:114158(PPT1 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human kidney using Catalog No:114158(PPT1 antibody) at dilution of 1:50 (under 40x lens)
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Background
The defective gene behind the INCL(infantile neuronal ceroid lipofuscinoses) disease, CLN1, encodes for palmitoyl protein thioesterase 1 (PPT1). It consists of 306 amino acids, including a signal sequence of 26 amino acids and three N-linked glycosylation sites. This protein exsits with the molecular mass of 32 kDa, 34 kDa,36 kDa and 38 kDa. The enzyme is transported into lysosomes of non-neuronal cells by the mannose 6-phosphate receptor (M6PR) mediated pathway and a significant amount of native PPT1 resides in a complex rather than in a monomeric form(PMID:17565660).
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