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  • PPP2R4 Polyclonal Antibody
  • PPP2R4 Polyclonal Antibody
  • PPP2R4 Polyclonal Antibody
  • PPP2R4 Polyclonal Antibody

PPP2R4 Polyclonal Antibody

Cat.#: 166651

Special Price 174.2 USD

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Product Information

  • Product Name
    PPP2R4 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to PPP2R4
  • Tested applications
    IHC, IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    PTPA antibody; PP2A antibody; PPP2R4 antibody; PR53 antibody; protein phosphatase 2 phosphatase activator antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human PPP2R4 (NP_821067.1).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    IHC 1:50 - 1:200
    IF 1:50 - 1:200
  • Validations

    Immunohistochemistry - PPP2R4 Polyclonal Antibody

    Immunohistochemistry - PPP2R4 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded rat brain using PPP2R4 Antibody at dilution of 1:200 (40x lens).

    Immunohistochemistry - PPP2R4 Polyclonal Antibody

    Immunohistochemistry - PPP2R4 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded human kidney cancer using PPP2R4 Antibody at dilution of 1:200 (40x lens).

    Immunohistochemistry - PPP2R4 Polyclonal Antibody

    Immunohistochemistry - PPP2R4 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded human esophageal cancer using PPP2R4 Antibody at dilution of 1:200 (40x lens).

    Immunohistochemistry - PPP2R4 Polyclonal Antibody

    Immunohistochemistry - PPP2R4 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded mouse kidney using PPP2R4 Antibody at dilution of 1:200 (40x lens).

  • Background
    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"