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PPP2R3A antibody

Cat.#: 114102

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Special Price 239.0 USD

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Product Information

  • Product Name
    PPP2R3A antibody
  • Documents
  • Description
    PPP2R3A Rabbit Polyclonal antibody. Positive IHC detected in human skin tissue, human brain tissue, human kidney tissue, human lung tissue, human ovary tissue, human placenta tissue, human spleen tissue, human testis tissue. Positive WB detected in PC-3 cells, MCF7 cells. Observed molecular weight by Western-blot: 130kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    PPP2R3 antibody; PPP2R3A antibody; PR130 antibody; PR72 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of PPP2R3A recombinant protein (Accession Number: XM_006713686). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:114102(PPP2R3A antibody) at dilution of 1:300

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:114102(PPP2R3A antibody) at dilution of 1:300

    Immunohistochemical of paraffin-embedded human skin using Catalog No:114102(PPP2R3A antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human skin using Catalog No:114102(PPP2R3A antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human skin using Catalog No:114102(PPP2R3A antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human skin using Catalog No:114102(PPP2R3A antibody) at dilution of 1:100 (under 40x lens)

  • Background
    PPP2R3A(Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha), also named as PPP2R3, has 2 isoforms produced by alternative splicing named as PR130 and PR72. The protein contains stretches of basic residues that may be putative nuclear localization signals, and a cluster of proline residues in an N-terminal region common to both isoforms that the isoform PR130 but not PR72 is variably expressed in a number of tumor cell lines. The PR72 and PR130 cDNAs encode 72 and 130 kDa proteins when expressed in rabbit reticulocyte lysates.(PMID:8392071).
  • References
    • Zhu XN, Chen LP, Bai Q. PP2A-AMPKα-HSF1 axis regulates the metal-inducible expression of HSPs and ROS clearance. Cellular signalling. 26(4):825-32. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"