POLR2B-Specific antibody

POLR2B-Specific antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

POLR2B-Specific Rabbit Polyclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in A431 cells, HeLa cells. Positive IHC detected in human brain tissue. Observed molecular weight by Western-blot: 140kd

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

hRPB140 antibody; hsRPB2 antibody; POL2RB antibody; POLR2B antibody; RNA polymerase II subunit 2 antibody; RNA polymerase II subunit B2 antibody; RPB2 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_000938). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

POLR2B belongs to the RNA polymerase beta chain family. It is a DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is the second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. POLR2B proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. The antibody is specific to POLR2B.