Human Podoplanin (His & Fc Tag) recombinant protein

Human Podoplanin (His & Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.

Podoplanin

HT1A-1; RP23-348F1.2; OTS-8; GP38; T1ALPHA; CTA-520D8.1; GP36; GP40; TI1A; T1A2; AGGRUS; PODOPLANIN; RANDAM-2; PA2.26; PDPN; T1A; T1A-2; T1-ALPHA; OTS8

Q86YL7

PDPN; GP36; PSEC0003; PSEC0025

Human Cells

A DNA sequence encoding the extracellular domain of human PDPN short isoform (Q86YL7-1) (Met 1-Lys 123) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Human

The recombinant human PDPN/Fc chimera is a disulfide-linked homodimer. The reduced monomer comprises 351 amino acids with a predicted molecular mass of 38.6 kDa. As a result of glycosylation, rh PDPN/Fc monomer migrates as an approximately 50-55 kDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA.
2. Immobilized human Podoplanin (Cat: 502218) at 10 μg/mL (100 μl/well) can bind biotinylated human CLEC1B-His (Cat:501731), The EC₅₀ of biotinylated human CLEC1B-His is 0.4-1.0 μg/mL.