PLXNB2 Polyclonal Antibody
Polyclonal antibody to PLXNB2
Human, Mouse, Rat
PLXNB2 antibody; MM1 antibody; Nbla00445 antibody; PLEXB2 antibody; dJ402G11.3 antibody; plexin-B2 antibody
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1080-1200 of human PLXNB2 (NP_036533.2).
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Store at -20℃. Avoid freeze / thaw cycles.
WB 1:500 - 1:2000
Western blot - PLXNB2 Polyclonal Antibody
Western blot analysis of extracts of various cell lines, using PLXNB2 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 90s.
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42 (By similarity).
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