PLSCR3 antibody

PLSCR3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PLSCR3 Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue, human skeletal muscle tissue.

ELISA, IHC

Human; other species not tested.

phospholipid scramblase 3 antibody; PL scramblase 3 antibody; PLSCR3 antibody

Rabbit IgG

This antibody was obtained by immunization of Recombinant Protein (Accession Number: NM_020360). Purification method: Protein A purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PLSCR3, also named as PLS3, belongs to the phospholipid scramblase family. It may mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. PLSCR3 may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. It is a target of protein kinase C-δ (PKC-δ), resides in mitochondria and plays pivotal roles in regulating apoptotic response. Phosphorylation of PLSCR3 by PKC-δ is involved in the hyperthermia-induced apoptotic signal transduction pathway in Tca8113 cells, and that Hsp27 blocks this pathway to suppress hyperthermia-induced apoptosis. (PMID:20569108)

• Jiang W, Bian L, Ma LJ, Tang RZ, Xun S, He YW. Hyperthermia-induced apoptosis in Tca8113 cells is inhibited by heat shock protein 27 through blocking phospholipid scramblase 3 phosphorylation. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 26(6):523-37. 2010.