Human PDGF-C (His Tag) recombinant protein

Human PDGF-C (His Tag) recombinant protein

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Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.

Platelet-derived growth factor C

PDGF-C; SCDGF; PDGFC latent form; PDGFC receptor-binding form

Q9NRA1

PDGFC; SCDGF; UNQ174/PRO200

Baculovirus-Insect Cells

A DNA sequence encoding the mature form of human PDGF-C (NP_057289.1) (Val 235-Gly 345) was fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.

Human

The recombinant human PDGF-C consists of 121 amino acids and predicts a molecular mass of 13.8 kDa. It migrates as an approximately 20 KDa band in SDS-PAGE under reducing conditions.

> 84 % as determined by SDS-PAGE