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Product Name
PLAGL2 antibody
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Description
PLAGL2 Rabbit Polyclonal antibody. Positive WB detected in Raji cells. Observed molecular weight by Western-blot: 50-55kd,70kd
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Tested applications
ELISA, WB
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
PLAGL2 antibody; KIAA0198 antibody; FLJ23283 antibody; Zinc finger protein PLAGL2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PLAGL2 recombinant protein (Accession Number: XM_011528864). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:113937(PLAGL2 antibody) at dilution of 1:300
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Background
PLAGL2, also named as KIAA0198, belongs to the krueppel C2H2-type zinc-finger protein family. It shows weak transcriptional activatory activity. PLAGL2), a proto-oncogene, is implicated in a variety of cancers including acute myeloid leukemia (AML), malignant glioma, colon cancer, and lung adenocarcinoma.PLAGL2 can function as a tumor suppressor by initiating cell cycle arrest and apoptosis.
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References
- Wezensky SJ, Hanks TS, Wilkison MJ, Ammons MC, Siemsen DW, Gauss KA. Modulation of PLAGL2 transactivation by positive cofactor 2 (PC2), a component of the ARC/Mediator complex. Gene. 452(1):22-34. 2010.
- Hanks TS, Gauss KA. Pleomorphic adenoma gene-like 2 regulates expression of the p53 family member, p73, and induces cell cycle block and apoptosis in human promonocytic U937 cells. Apoptosis : an international journal on programmed cell death. 17(3):236-47. 2012.
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