Cart 2
  • PL3 peptide

PL3 peptide

For research use only. We do not sell to patients.

Cat.#: 318901

Size:
Optional Service: TFA RemovalWhat's this?

Special Price 69.3 USD

Availability: 1-2 weeks
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    PL3 peptide
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    H-AGRGRLVR-OH
  • Three letter code
    H-Ala-Gly-Arg-Gly-Arg-Leu-Val-Arg-OH
  • Length (aa)
    8
  • Peptide Purity (HPLC)
    95.2
  • Molecular Formula
    C36H69N17O9
  • Molecular Weight
    884.04
  • Source
    Synthetic
  • Additional Information
    The Tenascin-C binding peptide PL3 (AGRGRLVR) is a CendR motif containing peptide. PL3 was identified by using the in vitro biopanning on recombinant Tenascin- C. PL3 functionalized iron oxide nanoworms (NW) or Ag-nanoparticles accumulated in the glioblastoma or pancreatic carcinoma xenografts in preclinical models and colocalized with Tenascin-C and NRP-1. In addition, treatment of glioblastoma-bearing mice with PL3-guided proapoptotic D(KLAKLAK)2-peptide containing NWs significantly inhibited tumor growth and prolonged the survival of the animals.
  • Storage Guidelines
    Ideally PL3 peptide should be stored in a freezer at or below -9C. PL3 peptide should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Lingasamy P, Tobi A, Kurm K, Kopanchuk S, Sudakov A, Salumäe M, et al. Tumor-penetrating peptide for systemic targeting of Tenascin-C. Sci Rep. 2020;10(1):5809
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"