PKMYT1 antibody

PKMYT1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PKMYT1 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, A375 cells, HeLa cells, HepG2 cells, HL-60 cells, mouse skin tissue. Observed molecular weight by Western-blot: 55kd

ELISA, WB

human, mouse, rat; other species not tested.

PKMYT1 antibody; MYT1 antibody; Myt1 kinase antibody; FLJ20093 antibody; DKFZp547K1610 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_004203). Purification method: Antigen affinity purified.

Polyclonal

0.1M NaHCO3, 0.1M glycine, 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PKMYT1, also named as MYT1, belongs to the protein kinase superfamily, Ser/Thr protein kinase family and WEE1 subfamily. It acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the cdc2 kinase specifically when cdc2 is complexed to cyclins. PKMYT1 mediates phosphorylation of cdc2 predominantly on 'Thr-14'. PKMYT1 also involved in Golgi fragmentation. May be involved in phosphorylation of cdc2 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. It may be a downstream target of Notch signaling pathway during eye development. The antibody is specific to PKMYT1.