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Product Name
PJA2 Polyclonal Antibody
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Description
Polyclonal antibody to PJA2
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Tested applications
WB, IF
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Species reactivity
Human, Mouse, Rat
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Alternative names
PJA2 antibody; Neurodap1 antibody; RNF131 antibody; E3 ubiquitin-protein ligase Praja-2 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 439-708 of human PJA2 (NP_055634.3).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
IF 1:50 - 1:100 -
Validations
Immunofluorescence - PJA2 Polyclonal Antibody
Immunofluorescence analysis of U2OS cells using PJA2 antibody . Blue: DAPI for nuclear staining.
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Background
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"