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  • Pinipesin peptide

Pinipesin peptide

Not For Human Use, Lab Use Only.

Cat.#: 318767

Size:
Optional Service: TFA RemovalWhat's this?

Special Price 95.3 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Pinipesin peptide
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    H-VAEARQGSFSY-OH
  • Three letter code
    H-Val-Ala-Glu-Ala-Arg-Gln-Gly-Ser-Phe-Ser-Tyr-OH
  • Length (aa)
    11
  • Peptide Purity (HPLC)
    95.2%
  • Molecular Formula
    C53H79N15O18
  • Molecular Weight
    1214.28
  • Source
    Synthetic
  • Additional Information
    Pinipesin is a novel antimicrobial peptide, present in the exuviae extract of the centipede Scolopendra subspinipes subspinipes. Pinipesin displayed potent antimicrobial effects against different microorganisms and showed low haemolytic effects against human erythrocytes at high concentrations. Its sequence exhibited high similarity with some cuticular proteins, and it might act intracellularly by interfering with protein synthesis. Pinipesin might be part of a prophylactic immune response during the ecdysis process of centipedes. Pinipesin is sensitive to plasma proteases – almost totally digested within 60 min.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Chaparro-Aguirre E, Segura-Ramu00edrez PJ, Alves FL, Riske KA, Miranda A, Silva Ju00fanior PI. Antimicrobial activity and mechanism of action of a novel peptide present in the ecdysis process of centipede Scolopendra subspinipes subspinipes. Sci Rep. 2019;9(1):13631
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

  • Analysed Sequence:H-VAEARQGSFSY-OH
  • Chemical Formula:C53H79N15O18
  • Sequence length:11
  • Extinction coefficient:1280 M-1cm-1
  • GRAVY:-0.38
  • Mw average:1214.28
  • Theoretical pI:7
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"