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  • Phospho-REL-S503 pAb

Phospho-REL-S503 pAb

Cat.#: 166449

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Product Information

  • Product Name
    Phospho-REL-S503 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-REL-S503
  • Tested applications
    IF
  • Species reactivity
    Human
  • Alternative names
    REL antibody; C-Rel antibody; proto-oncogene c-Rel antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A phospho specific peptide corresponding to residues surrounding S503 of human REL
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    IF 1:100 - 1:200
  • Validations

    Immunofluorescence - Phospho-REL-S503 pAb

    Immunofluorescence - Phospho-REL-S503 pAb

    Immunofluorescence analysis of methanol-fixed HeLa cells using Phospho-REL-S503 antibody .

  • Background
    Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
  • References

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