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  • Phospho-NF2-S518 pAb
  • Phospho-NF2-S518 pAb

Phospho-NF2-S518 pAb

Cat.#: 166437

Special Price 232.3 USD

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Product Information

  • Product Name
    Phospho-NF2-S518 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-NF2-S518
  • Tested applications
    WB, IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    NF2 antibody; ACN antibody; BANF antibody; SCH antibody; merlin antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A phospho specific peptide corresponding to residues surrounding S518 of human NF2
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IF 1:100 - 1:200
  • Validations

    Western blot - Phospho-NF2-S518 pAb

    Western blot - Phospho-NF2-S518 pAb

    Western blot analysis of extracts from HUVEC cells, using Phospho-NF2-S518 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.

    Immunofluorescence - Phospho-NF2-S518 pAb

    Immunofluorescence - Phospho-NF2-S518 pAb

    Immunofluorescence analysis of methanol-fixed HeLa cells using Phospho-NF2-S518 antibody .

  • Background
    Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"