phospho(403/404)-TDP43 antibody

phospho(403/404)-TDP43 antibody

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• Material Safety Data Sheets (MSDS)

phospho(403/404)-TDP43 Mouse Monoclonal antibody. Positive WB detected in K-562 cells, human placenta tissue. Observed molecular weight by Western-blot: 25 kDa

ELISA, WB

Human; other species not tested.

ALS10 antibody; TAR DNA binding protein antibody; TAR DNA binding protein 43 antibody; TARDBP antibody; TDP 43 antibody; TDP43 antibody

Mouse IgG2a

This antibody was obtained by immunization of Peptide (Accession Number: NM_007375). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Transactivation response (TAR) DNA-binding protein of 43 kDa (also known as TARDBP or TDP-43) was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U). 66079-1-Ig is a mouse monoclonal antibody recognizing TDP-43 only when phosphorylated at 403/404. This antibody detects phosphorylated forms of TDP-43 as well as the cleavage product of 20-30 kDa. Immunohistochemical analyses using this antibody only stain the insoluble inclusions in pathologic tissues without normal diffuse nuclear staining.

• Kovacs GG, van der Zee J, Hort J. Clinicopathological description of two cases with SQSTM1 gene mutation associated with frontotemporal dementia. Neuropathology : official journal of the Japanese Society of Neuropathology. 36(1):27-38. 2016.