Human PTPMT1 (His Tag) recombinant protein

Human PTPMT1 (His Tag) recombinant protein

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Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

MOSP; DUSP23; PLIP; 1110001D10RIK; 2810004N20RIK; PNAS-129

Q8WUK0

PTPMT1; MOSP; PLIP; PNAS-129

E. coli

A DNA sequence encoding the human PTPMT1 isoform 1 (Q8WUK0-1) (Lys 28-Thr 201) was expressed, with a polyhistidine tag at the N-terminus.

Human

The recombinant human PTPMT1 consisting of 190 amino acids and has a calculated molecular mass of 21.7 kDa. It migrates as an 20 kDa band in SDS-PAGE under reducing conditions as predicted.

> 94 % as determined by SDS-PAGE

Measured by its ability to cleave pNPP.
The specific activity is >200 pmoles/min/μg.