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PHF11 antibody

Cat.#: 113806

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Special Price 239.0 USD

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Product Information

  • Product Name
    PHF11 antibody
  • Documents
  • Description
    PHF11 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HEK-293 cells, mouse thymus tissue. Positive IHC detected in human lymphoma tissue. Observed molecular weight by Western-blot: 34kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    APY antibody; IGEL antibody; IGER antibody; IGHER antibody; NY REN 34 antibody; NYREN34 antibody; PHD finger protein 11 antibody; PHF11 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of PHF11 recombinant protein (Accession Number: NM_001040444). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:113806(PHF11 antibody) at dilution of 1:300

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:113806(PHF11 antibody) at dilution of 1:300

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:113806(PHF11 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:113806(PHF11 antibody) at dilution of 1:100 (under 10x lens)

  • Background
    PHF11 is a transcriptional co-activator of the Th1 effector cytokine genes, interleukin-2 (IL2) and interferon-γ (IFNG), co-operating with nuclear factor kappa B (NF-κB). The reduction in PHF11 expression seen with an AD-associated genotype could contribute to the strong T(H)2 responses that characterize many allergic individuals.
  • References
    • Rahman N, Stewart G, Jones G. A role for the atopy-associated gene PHF11 in T-cell activation and viability. Immunology and cell biology. 88(8):817-24. 2010.
    • Muscat P, Mercado K, Payne K, Chahal H, Jones G. PHF11 expression and cellular distribution is regulated by the Toll-Like Receptor 3 Ligand Polyinosinic:Polycytidylic Acid in HaCaT keratinocytes. BMC immunology. 16:69. 2015.
    • Clarke E, Rahman N, Page N, Rolph MS, Stewart GJ, Jones GJ. Functional characterization of the atopy-associated gene PHF11. The Journal of allergy and clinical immunology. 121(5):1148-1154.e3. 2008.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"