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PFKFB2 antibody

Cat.#: 113769

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Product Information

  • Product Name
    PFKFB2 antibody
  • Documents
  • Description
    PFKFB2 Rabbit Polyclonal antibody. Positive WB detected in human heart tissue, mouse brain tissue, rat brain tissue. Positive IHC detected in human spleen tissue. Observed molecular weight by Western-blot: 58 kDa, 110 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    6PF 2 K/Fru 2 antibody; 6 P2ase 2 antibody; DKFZp781D2217 antibody; PFK 2/FBPase 2 antibody; PFK/FBPase 2 antibody; PFKFB2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of PFKFB2 recombinant protein (Accession Number: XM_047422548). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:113769(PFKFB2 antibody) at dilution of 1:500

    human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:113769(PFKFB2 antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human spleen using Catalog No:113769(PFKFB2 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human spleen using Catalog No:113769(PFKFB2 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human spleen using Catalog No:113769(PFKFB2 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human spleen using Catalog No:113769(PFKFB2 antibody) at dilution of 1:100 (under 40x lens)

  • Background
    PFKFB2(6-Phosphofructo-2-kinase/fructose 2,6-bisphosphatase 2) is also named as PFK-2/FBPase-2, which is a bifunctional enzyme responsible for the synthesis and breakdown of Fru-2,6-P2, a key metabolite in the regulation of glycolysis(PMID:10095107). In the C-terminal section, it belongs to the phosphoglycerate mutase family.The enzyme is a dimer of identical subunits, each composed of 505 amino acids and containing three discrete domains(PMID: 2552438). It has 2 isoforms produced by alternative splicing.
  • References
    • Telang S, Clem BF, Klarer AC. Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation. Journal of translational medicine. 10:95. 2012.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"