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Product Name
PDYN Polyclonal Antibody
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Description
Polyclonal antibody to PDYN
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Tested applications
WB, IHC
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Species reactivity
Human, Mouse, Rat
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Alternative names
PDYN antibody; ADCA antibody; PENKB antibody; SCA23 antibody; prodynorphin antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 21-254 of human PDYN (NP_077722.1).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
IHC 1:50 - 1:200 -
Validations
Western blot - PDYN Polyclonal Antibody
Western blot analysis of extracts of various cell lines, using PDYN antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 90s.
Immunohistochemistry - PDYN Polyclonal Antibody
Immunohistochemistry of paraffin-embedded rat brain using PDYN antibody at dilution of 1:100 (40x lens).
Immunohistochemistry - PDYN Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human lung cancer using PDYN antibody at dilution of 1:100 (40x lens).
Immunohistochemistry - PDYN Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human gastric cancer using PDYN antibody at dilution of 1:100 (40x lens).
Immunohistochemistry - PDYN Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human rectal cancer using PDYN antibody at dilution of 1:100 (40x lens).
Immunohistochemistry - PDYN Polyclonal Antibody
Immunohistochemistry of paraffin-embedded mouse brain using PDYN antibody at dilution of 1:100 (40x lens).
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Background
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).; Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).; Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"