PDX1 Polyclonal Antibody

Cat.#: 164005

Special Price 174.2 USD

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Product Information

  • Product Name
    PDX1 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to PDX1
  • Tested applications
    WB
  • Species reactivity
    Mouse
  • Alternative names
    PDX1 antibody; GSF antibody; IDX-1 antibody; IPF1 antibody; IUF1 antibody; MODY4 antibody; PAGEN1 antibody; PDX-1 antibody; STF-1 antibody; pancreatic and duodenal homeobox 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human PDX1
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:1000
  • Validations

    Western blot - PDX1 Polyclonal Antibody

    Western blot - PDX1 Polyclonal Antibody

    Western blot analysis of extracts of mouse intestine, using PDX1 antibody at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.

  • Background
    Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"