PDX1 antibody

PDX1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PDX1 Rabbit Polyclonal antibody. Positive WB detected in BGC-823 cells, PC-3 cells. Observed molecular weight by Western-blot: 35-40 kDa

ELISA, WB

Human; other species not tested.

Glucose sensitive factor antibody; GSF antibody; IDX 1 antibody; Insulin promoter factor 1 antibody; Insulin upstream factor 1 antibody; IPF 1 antibody; IPF1 antibody; Islet/duodenum homeobox 1 antibody; IUF 1 antibody; IUF1 antibody; MODY4 antibody; PDX 1 antibody; PDX1 antibody; STF 1 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_000209). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Pancreatic duodenal homeobox-1 protein (PDX-1), also designated insulin promoter factor (IPF1), insulin upstream factor 1 (IUF1), somatostatin trans-activating factor-1 (STF-1) and glucose-sensitive factor (GSF), is a 282 amino acid homeodomain-containing transcription factor present in pancreatic beta-cells. PDX-1 is a key regulator of pancreatic islet development and insulin gene transcription in beta-cells. PDX-1 is expressed in all cells at the early stages of development and is mainly restricted to the pancreas and duodenum in adult. HNF-3b, HNF-1a and SP1 positively regulate the PDX-1 enhancer element. PDX-1 is also regulated by glucagon-like peptide through activation of adenylyl cyclase, which results in an increase in intracellular cAMP activity. The increased levels of cAMP, and the resulting activation of PKA, lead to an increase in PDX-1 transcription and translocation of the protein to the nuclei of beta-cells. PDX-1 binds to the sequence C(C/T) and can heterodimerize with PBX. PDX-1 is phosphorylated by the SAPK2 pathway under high glucose concentrations. Mutations in the PDX-1 gene can cause maturity-onset diabetes of the young and pancreatic agenesis.