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Product Name
PDE2A antibody
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Description
PDE2A Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, mouse heart tissue. Positive IHC detected in human kidney tissue, human liver cancer tissue. Observed molecular weight by Western-blot: 100-106 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CGS PDE antibody; cGSPDE antibody; PDE2A antibody; PDE2A1 antibody; PED2A4 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_002599). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113659(PDE2A antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human kidney using Catalog No:113659(PDE2A antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human kidney using Catalog No:113659(PDE2A antibody) at dilution of 1:50 (under 40x lens)
IP Result of anti-PDE2A (IP:Catalog No:113659, 4ug; Detection:Catalog No:113659 1:500) with mouse brain tissue lysate 3440ug.
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Background
PDE2A, also named as cGSPDE and CGS-PDE, belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. It is a cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. This antibody is specific to PDE2A.
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References
- Módis K, Panopoulos P, Coletta C, Papapetropoulos A, Szabo C. Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A. Biochemical pharmacology. 86(9):1311-9. 2013.
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