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PDCD5 antibody

Cat.#: 113766

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Product Information

  • Product Name
    PDCD5 antibody
  • Documents
  • Description
    PDCD5 Rabbit Polyclonal antibody. Positive WB detected in human heart tissue, human brain tissue, mouse testis tissue, PC-3 cells. Positive IHC detected in human skin cancer tissue, human colon cancer tissue, human colon tissue. Observed molecular weight by Western-blot: 14 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    PDCD5 antibody; programmed cell death 5 antibody; Protein TFAR19 antibody; TFAR19 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of PDCD5 recombinant protein (Accession Number: NM_004708). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:113766(PDCD5 antibody) at dilution of 1:500

    human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:113766(PDCD5 antibody) at dilution of 1:500

    Immunohistochemistry of paraffin-embedded human skin cancer tissue slide using Catalog No:113766(PDCD5 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human skin cancer tissue slide using Catalog No:113766(PDCD5 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human skin cancer tissue slide using Catalog No:113766(PDCD5 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human skin cancer tissue slide using Catalog No:113766(PDCD5 Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    PDCD5, also called TFAR19 (TF1 cell apoptosis-related gene 19), was first identified as a gene up-regulated in TF-1 cells under-going apoptosis (PMID: 9920759). PDCD5 can promote pro-grammed cell death in different cell types in response to various stimuli and also enhance TAJ/TROY-induced paraptosis-like cell death (PMID: 15020679). During apoptosis, PDCD5 is rapidly upregulated and translocates from the cytoplasm to nucleus (PMID: 11741587). PDCD5 is a positive regulator of Tip60 and also has a potential ability to interact with p53 (PMID: 22914926, PMID: 19308289). Recent studies have also revealed that PDCD5 may be a suppressor gene and expressed at lower levels in many cancers, including hepatocellular carcinoma, breast cancer, gastric cancer, cervical cancer, lung cancer, astrocytic gliomas, and in leukemia.
  • References
    • Bock FJ, Tanzer MC, Haschka MD. The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death. Scientific reports. 5:11268. 2015.
    • Choi HK, Choi Y, Park ES. Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response. Nature communications. 6:7390. 2015.
    • Li K, Zhou Z, Wang YO. Pretreatment of mice with oligonucleotide prop5 protects them from influenza virus infections. Viruses. 6(2):573-81. 2014.
    • Xu S, Sui G, Yuan L, Zou Z. Expression of programmed cell death 5 protein inhibits progression of lung carcinoma in vitro and in vivo via the mitochondrial apoptotic pathway. Molecular medicine reports. 10(4):2059-64. 2014.
    • Cui X, Choi HK, Choi YS. DNAJB1 destabilizes PDCD5 to suppress p53-mediated apoptosis. Cancer letters. 357(1):307-15. 2015.
    • Park SY, Choi HK, Jo SH. YAF2 promotes TP53-mediated genotoxic stress response via stabilization of PDCD5. Biochimica et biophysica acta. 1853(5):1060-72. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"