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Product Name
PC6 antibody
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Description
PC6 Rabbit Polyclonal antibody. Positive IHC detected in human brain tissue, human heart tissue, human kidney tissue, human placenta tissue, human skin tissue, human spleen tissue, human testis tissue. Positive WB detected in mouse brain tissue.
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Tested applications
ELISA, IHC, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
hPC6 antibody; PC5 antibody; PC6 antibody; PC6A antibody; PCSK5 antibody; Proprotein convertase 5 antibody; Proprotein convertase 6 antibody; SPC6 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PC6 recombinant protein (Accession Number: NM_006200). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human brain using Catalog No:113618(PC5 antibody) at dilution of 1:200 (under 10x lens)
Immunohistochemical of paraffin-embedded human brain using Catalog No:113618(PC5 antibody) at dilution of 1:200 (under 40x lens)
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113618(PC5 Antibody) at dilution of 1:300
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Background
PC5 ,a mammalian kex2-like processing endoprotease, mediates posttranslational endoproteolytic processing for several integrin alpha subunits.It has been identified in rat and mouse endocrine and neuroendocrine tissues,and is encoded by multiple mRNAs that generate two splice variant isoforms referred to as PC5A (102KDa) and PC5B (207KDa) .PC5A is smaller than PC5B and it can be processed into two forms (117 kDa and 65 kDa) in neuronal cells(PMID:11457520).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"