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Product Name
PAX8-Specific antibody
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Description
PAX8-Specific Mouse Monoclonal antibody. Positive WB detected in Skov-3 cells. Positive IHC detected in human thyroid tissue, human ovary tumor tissue. Observed molecular weight by Western-blot: 48kD
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
paired box 8 antibody; Paired box protein Pax 8 antibody; PAX8 antibody
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Isotype
Mouse IgG2b
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_013992). Purification method: Protein A purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
SKOV-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:107455(PAX8-Specific antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human thyroid using Catalog No:107455(PAX8-Specific antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human thyroid using Catalog No:107455(PAX8-Specific antibody) at dilution of 1:50 (under 40x lens)
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Background
PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Several other splice variants have been proposed but the full nature of these products has not been described. Pax8 is also a marker of otic progenitor cells. Mutation of PAX8 will cause congenital hypothyroidism non-goitrous type 2 (CHNG2). This antibody is specific to Pax8. It will not cross react with other PAX members
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"