PAX8 antibody

PAX8 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PAX8 Mouse Monoclonal antibody. Positive IHC detected in human ovary tumor. Positive WB detected in Hepg2 cells. Observed molecular weight by Western-blot: 48kd

ELISA, WB, IHC

human; other species not tested.

PAX8 antibody; paired box 8 antibody; Paired box protein Pax 8 antibody

Mouse IgG2b

This antibody was obtained by immunization of PAX8 recombinant protein (Accession Number: NM_003466). Purification method: Protein A purified.

Monoclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX8 has 5 isoforms with calculated MW 31kd, 34kd, 41kd, 43kd and 48kd. And there is a 60kd band corresponding to the electrophoretic mobility of PAX8 (PMID:15650356).