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Product Name
Human PNLIP (His Tag) recombinant protein
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Description
PNLIP is an enzyme which belongs to the lipase family. Secreted from the pancreas, PNLIP is the primary lipase that hydrolyzes dietary fat molecules in the human digestive system, converting triglyceride substrates found in ingested oils to monoglycerides and free fatty acids. Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which allows the lipase to break apart the fat more effectively. The resulting monomers (2 free fatty acids and one 2-monoacylglycerol) are then moved by way of peristalsis along the small intestine to be absorbed into the lymphatic system by a specialized vessel called a lacteal.
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Protein name
Pancreatic triacylglycerol lipase
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Protein short names
PANCREATIC TRIACYLGLYCEROL LIPASE; TRIACYLGLYCEROL ACYLHYDROLASE; PTL; RP11-33D13.1; PANCREATIC TRIGLYCERIDE LIPASE; 1810007A24RIK; PNLIPD; PL
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Uniprot ID
P16233
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Gene Name
PNLIP
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human PNLIP (P16233) (Met1-Cys465) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human PNLIP consists of 460 amino acids and predicts a molecular mass of 51 KDa. It migrates as an approximately 51 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human PNLIP Protein (His Tag) SDS-PAGE
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