PAFAH antibody

PAFAH antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PAFAH Rabbit Polyclonal antibody. Positive IHC detected in human tonsillitis tissue, human colon cancer tissue, human prostate cancer tissue. Positive WB detected in RAW 264.7 cells, mouse liver tissue, mouse spleen tissue, RAW264.7 cells. Observed molecular weight by Western-blot: 43-67 kDa

ELISA, WB, IHC

Human, Mouse; other species not tested.

Group VIIA phospholipase A2 antibody; gVIIA PLA2 antibody; LDL PLA(2) antibody; LDL PLA2 antibody; Lp-PLA2 antibody; PAF 2 acylhydrolase antibody; PAF acetylhydrolase antibody; PAFAH antibody; PAF-AH antibody; PLA2G7 antibody

Rabbit IgG

This antibody was obtained by immunization of PAFAH recombinant protein (Accession Number: NM_001168357). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PAFAH(platelet-activating factor acetylhydrolase, plasma) is also named as PLA2G7(phospholipase A2, group VII), Lp-PLA2 (Lipoprotein-associated phospholipase A2), LDL-PLA2, LDL-PLA and belongs to the AB hydrolase superfamily and lipase family. It is an enzyme which catalyzes the hydrolysis of acetyl ester at the sn-2 position of PAF. The family of PAF-Ahs consists of two intracellular isoforms (Ib and II), and one secreted isoform (plasma). Plasma PAF-AH is a monomeric polypeptide with a molecular weight of 45 kDa and it can show broad bands with a molecular weight of 43-67 kDa that it can be extensively N-glycosylated(PMID:12547653). Defects in PLA2G7 are the cause of platelet-activating factor acetylhydrolase deficiency (PAFAD), susceptibility to asthma (ASTHMA), susceptibility to atopic hypersensitivity (ATOPY).

• Das A, Tanigawa S, Karner CM. Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nature cell biology. 15(9):1035-44. 2013.