p107 antibody

p107 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

p107 Rabbit Polyclonal antibody. Positive WB detected in mouse testis tissue, COLO 320 cells. Positive IP detected in mouse testis tissue. Observed molecular weight by Western-blot: 119 kDa

ELISA, WB, IP

Human,Mouse,Rat; other species not tested.

CP107 antibody; p107 antibody; PRB1 antibody; RBL1 antibody; retinoblastoma like 1 (p107) antibody; Retinoblastoma like protein 1 antibody

Rabbit IgG

This antibody was obtained by immunization of p107 recombinant protein (Accession Number: NM_183404). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Retinoblastoma-like protein 1, also named RBL1, p107, is a member of E1A-binding proteins, which contains a A/B pocket, or pRb. Via this structure, RBL1 can bind to viral oncoproteins and other perteins containing LXCXE motif. It regulates cell proliferation via phosphorylation-sensitive interactions with E2F transcription factors and other proteins. Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression.(uniprot). It has been reported there are two transcirpts variants of RBL1, which encode a 119-kd protein and a 68-kd protein(PMID:7490090).

• Guo L, Song L, Wang Z, Zhao W, Mao W, Yin M. Panaxydol inhibits the proliferation and induces the differentiation of human hepatocarcinoma cell line HepG2. Chemico-biological interactions. 181(1):138-43. 2009.