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Product Name
ORM1/2 antibody
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Description
ORM1/2 Mouse Monoclonal antibody. Positive IHC detected in human liver tissue, human liver cancer tissue. Positive IF detected in HepG2 cells. Positive WB detected in Human Blood. Observed molecular weight by Western-blot: 41kDa
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Tested applications
ELISA, WB, IF, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
AGP 1 antibody; AGP A antibody; AGP1 antibody; Alpha 1 acid glycoprotein 1 antibody; OMD 1 antibody; ORM antibody; ORM1 antibody; orosomucoid 1 antibody
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Isotype
Mouse IgG1
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Preparation
This antibody was obtained by immunization of ORM1/2 recombinant protein (Accession Number: NM_000607). Purification method: Protein G purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:1000-1:10000
IHC: 1:20-1:200
IF: 1:10-1:100
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Validations
human blood tissue were subjected to SDS PAGE followed by western blot with Catalog No:107437(ORM1 antibody) at dilution of 1:2000
Immunohistochemistry of paraffin-embedded human liver slide using Catalog No:107437(ORM1 Antibody) at dilution of 1:50
Immunofluorescent analysis of HepG2 cells, using ORM1 antibody Catalog No: at 1:25 dilution and Rhodamine-labeled goat anti-mouse IgG (red).
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Background
Alpha-1-acid glycoprotein 1 (AGP1), also called orosomucoid-1 (ORM1), is a glycoprotein synthesized mostly by hepatocytes and present in human plasma. ORM1 is an acute-phase reactant protein controlled by glucocorticoids, interleukin-1 and interleukin-6, and increase up to 5-50 times upon infection and/or inflammation. Anti-apoptotic effect and role as immunomodulator of ORM have been reported. ORM is an important carrier for synthetic drugs and influences their distribution and availability in the body. This antibody recognizes a band about 44 kDa in human plasma which may be due to the glycosylation of ORM1 or the dimer formation of the protein. This anibody recognizes both ORM1 and ORM2.
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