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Product Name
OPRL1 Polyclonal Antibody
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Description
Polyclonal antibody to OPRL1
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Tested applications
WB
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Species reactivity
Human, Mouse
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Alternative names
OPRL1 antibody; KOR-3 antibody; NOCIR antibody; NOP antibody; NOPr antibody; OOR antibody; ORL1 antibody; nociceptin receptor antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human OPRL1
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
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Validations
Western blot - OPRL1 Polyclonal Antibody
Western blot analysis of extracts of various cell lines, using OPRL1 antibody at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit .
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Background
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"