Mouse OBCAM/OPCML (His Tag) recombinant protein

Mouse OBCAM/OPCML (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Opioid-binding Cell Adhesion Molecule (OBCAM), also known as OPCML, is a GPI-anchored cell adhesion molecule in the plasma membrane. This neuron-specific protein, consists of three immunoglobulin (Ig)-like domains anchored to the membrane through a glycosylphosphatidylinositol (GPI)-tail. OPCML also belongs to the member of the IgLON family, a subgroup of the immunoglobulin superfamily, consisting of three members, LAMP, OBCAM, and Neurotrimin. These molecules interact homophilically and heterophilically within the family, and OBCAM acts only as heterodimers with LAMP or Neurotrimin and possibly inhibits neurite outgrowth from cerebellar granule cells. OBCAM has been presumed to play a role as a cell adhesion/recognition molecule. Furthermore, the OPCML protein defects may play an important role in the carcinogenesis of cervical or ovarian cancers, and this gene is regarded as a candidate TSG (tumor suppressor gene).

Opioid binding protein/cell adhesion molecule-like

2900075O15RIK; B930023M13RIK; MGC99974; C230027C17; OPCML; OBCAM; AI844366; GM181; 3732419F12; IGLON1; OPCM

Q6DFY2

Opcml

Human Cells

A DNA sequence encoding the mouse OPCML (NP_808574.2) (Ala5-Val313) was expressed with a C-terminal polyhistidine tag.

Mouse

The recombinant mouse OPCML comprises 295 amino acids and has a predicted molecular mass of 32.7 kDa. The apparent molecular mass of the protein is approximately 44-55 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 95 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA.
2. Immobilized mouse OPCmL-His at 10μg/mL (100μL/well) can bind human LSAMP-Fc (Cat:500024).
The EC₅₀ of human LSAMP-Fc (Cat:500024) is 0.04-0.1 μg/mL.