Cart 2

Mouse Oncostatin M/OSM (His Tag) recombinant protein

Cat.#: 502148

Size:

Special Price 547.2 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Mouse Oncostatin M/OSM (His Tag) recombinant protein
  • Documents
  • Description
    Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells (By similarity). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).
  • Protein name
    Oncostatin-M
  • Protein short names
    MGC20461; RP23-453B22.1; ONCOSTATIN M; OSM; ONCOM
  • Uniprot ID
    P53347
  • Gene Name
    Osm
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of mouse OSM (P53347) (Met 1-Arg 206) was expressed, with a C-terminal polyhistidine tag.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse OSM comprises 193 amino acids and has a calculated molecular mass of 22 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 35-40 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    1. Measured by its ability to inhibit the proliferation of M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 50-200 ng/mL.
    2. Measured in a cell proliferation assay using NIH3T3 cells. The ED50 for this effect is typically 0.8-4 ng/mL.
  • Validations

    Mouse Oncostatin M / OSM Protein (His Tag) SDS-PAGE

    Mouse Oncostatin M / OSM Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"