Human Oncostatin M/OSM recombinant protein

Human Oncostatin M/OSM recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that signals through cell surface receptors type?and type? both of which share the similarity of containing protein gp130 and takes part in many biometabolism processes including liver development, haematopoeisis, inflammation, bone formation and destruction and possibly CNS development. Oncostatin M (OSM) was previoustly identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6 and G-CSF, has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degree but is not stable at 90 degrees. The human OSM is produced as a precursor containing 252 amino acids, whose first 25 amino acids function as a secretory signal peptide and which on removal yields the soluble 227 amino acid pro-OSM. Removal of the C-teminal most 31 amino acids produces the fully active 196 residue form.

Oncostatin-M

ONCOSTATIN M; RP23-453B22.1; ONCOM; OSM; MGC20461

P13725

OSM

Human Cells

A DNA sequence encoding the human OSM (NP_065391.1) (Met1-Arg221) was expressed.

Human

The recombinant human OSM consists 196 amino acids and predicts a molecular mass of 22.2 kDa.

> 95 % as determined by SDS-PAGE.

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
The ED₅₀ for this effect is typically 0.2-1 ng/mL.