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  • Omega76

Omega76

Cat.#: 318759

Size:
Optional Service: TFA RemovalWhat's this?

Special Price 157.4 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Omega76
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    H-FLKAIKKFGKEFKKIGAKLK-OH
  • Three letter code
    H-Phe-Leu-Lys-Ala-Ile-Lys-Lys-Phe-Gly-Lys-Glu-Phe-Lys-Lys-Ile-Gly-Ala-Lys-Leu-Lys-OH
  • Length (aa)
    20
  • Peptide Purity (HPLC)
    95.2
  • Molecular Formula
    C114H192N28O23
  • Molecular Weight
    2322.91
  • Source
    Synthetic
  • Additional Information
    Omega76 is a designed antimicrobial peptide to combat carbapenem- and tigecycline-resistant Acinetobacter baumannii. Omega76 displayed in vitro and in vivo efficacy against carbapenem- and tigecycline-resistant organisms and negligible in vivo toxicity at sublethal doses. Omega76 localizes within and disrupts bacterial membranes, inducing small-molecule leakage, resulting in rapid bactericidal activity. Omega76 adopts an a-helical structure in apolar solvents.
  • Storage Guidelines
    Ideally Omega76 should be stored in a freezer at or below -9C. Omega76 should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Nagarajan D, Roy N, Kulkarni O, et al. u03a976: A designed antimicrobial peptide to combat carbapenem- and tigecycline-resistant Acinetobacter baumannii. Sci Adv. 2019;5(7):eaax1946
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"