OFD1 antibody

OFD1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

OFD1 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, SH-SY5Y cells. Positive IHC detected in human brain tissue. Observed molecular weight by Western-blot: 43 kda

ELISA, IHC, WB

Human; other species not tested.

71 7A antibody; CXorf5 antibody; OFD1 antibody; oral facial digital syndrome 1 antibody; Protein 71 7A antibody; SGBS2 antibody

Rabbit IgG

This antibody was obtained by immunization of OFD1 recombinant protein (Accession Number: NM_001330209). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

OFD1,also named as CXorf5 and 71-7A, belongs to the OFD1 family. It has been implicated in several developmental syndromes, including a male-lethal X-linked dominant condition,Oral-Facial-Digital type 1 (OFD1) syndrome, X-linked recessiveSimpson-Golabi-Behmel syndrome type 2 (SGBS2) and Joubert syndrome and related disorders (JSRDs). It is a component of the centrioles controlling mother and daughter centrioles length. It is recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. OFD1 plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. This antibody recognize all the isoforms of OFD1. The 43 kDa is isoform 2. The ~80 kDa band is unknown.

• Shin JH, Kim PS, Kim ES. BIX-01294-induced autophagy regulates elongation of primary cilia. Biochemical and biophysical research communications. 460(2):428-33. 2015.