OCT4 antibody

OCT4 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

OCT4 Mouse Monoclonal antibody. Positive WB detected in human brain tissue, HEK-293 cells. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 50-52KD

ELISA, WB, IHC

Human,Mouse; other species not tested.

OCt 3 antibody; OCt 4 antibody; OCT3 antibody; OCT3/4 antibody; OCT4 antibody; OCtamer binding protein 3 antibody; OCtamer binding protein 4 antibody; OTF 3 antibody; OTF3 antibody; OTF4 antibody; POU class 5 homeobox 1 antibody; POU5F1 antibody

Mouse IgG1

This antibody was obtained by immunization of ℃T4 recombinant protein (Accession Number: BC020712). Purification method: Protein G purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Expression of the ocT4 transcription factor is associated with an undifferentiated phenotype of human and mouse embryonic stem cells and germ cells. ocT4 (octamer-4) is a homeodomain transcription factor of the POU family (POU5F1) involved in regulation of pluripotency during normal development and is detectable in embryonic stem (ES) and germ cells. Its expression is associated with an undifferentiated phenotype and tumors. In fact, gene knockdown of ocT4 promotes differentiation, thereby demonstrating a role for this factor in human ES cell self-renewal. As such, it is frequently used as a marker for undifferentiated ES cells or iPS (induced pluripotent stem) cells. ocT4 is one of the four key transcription factors (ocT4, SOX2, c-MYC, and KLF4) used to reprogram mouse and human fibroblasts to a pluripotent state as well as generate patient-specific iPS cells.