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Product Name
OCRL antibody
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Description
OCRL Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HEK-293 cells, mouse brain tissue, rat brain tissue, SH-SY5Y cells. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 105 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
INPP5F antibody; LOCR antibody; OCRL antibody; OCRL1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ℃RL recombinant protein (Accession Number: NM_001587). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:1000
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:113468(ocRL antibody) at dilution of 1:300
IP Result of anti-ocRL (IP:Catalog No:113468, 4ug; Detection:Catalog No:113468 1:300) with HeLa cells lysate 1080ug.
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Background
ocRL is also named as INPP5F, ocRL1 and belongs to the 5-phosphatase gene family and that Lowe syndrome represents an inborn error of inositol phosphate metabolism(PMID: 9430698).The protein product of the gene that when mutated is responsible for Lowe syndrome, or oculocerebrorenal syndrome (ocRL), is an inositol polyphosphate 5-phosphatase.It may function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes.It has 2 isoforms produced by alternative splicing.Defects in ocRL are the cause of Lowe oculocerebrorenal syndrome (ocRL) and Dent disease type 2 (DD2).This antibody is specific to ocRL.
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