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Product Name
OAS3 antibody
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Description
OAS3 Rabbit Polyclonal antibody. Positive IHC detected in human skin cancer tissue, human brain tissue. Positive IF detected in HeLa cells. Positive WB detected in A375 cells, HeLa cells, human placenta tissue. Observed molecular weight by Western-blot: 100 kDa
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Tested applications
ELISA, WB, IHC, IF
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Species reactivity
Human; other species not tested.
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Alternative names
(2 5)oligo(A) synthase 3 antibody; 2 5 oligoadenylate synthase 3 antibody; 2 5A synthase 3 antibody; OAS3 antibody; p100 antibody; p100 OAS antibody; p100OAS antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of OAS3 recombinant protein (Accession Number: NM_006187). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:20-1:200
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Validations
A375 cells were subjected to SDS PAGE followed by western blot with Catalog No:113461(OAS3 antibody) at dilution of 1:800
Immunohistochemistry of paraffin-embedded human skin cancer tissue slide using Catalog No:113461(OAS3 Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human skin cancer tissue slide using Catalog No:113461(OAS3 Antibody) at dilution of 1:50 (under 40x lens)
Immunofluorescent analysis of HeLa cells using Catalog No:113461(OAS3 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
The 2-prime,5-prime oligoadenylate synthetases (OASs), such as OAS3, are interferon-induced proteins characterized by their capacity to catalyze the synthesis of 2-prime,5-prime oligomers of adenosine (2-5As). It is also named as p100 OAS and belongs to the 2-5A synthase family. OAS3 is involved in inhibition of cellular protein synthesis and in viral infection resistance.
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