OAS2 antibody

OAS2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

OAS2 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 66-71kd

ELISA, WB

Human; other species not tested.

(2 5)oligo(A) synthase 2 antibody; 2 5 oligoadenylate synthase 2 antibody; 2 5A synthase 2 antibody; OAS2 antibody; p69 OAS / p71 OAS antibody; p69OAS / p71OAS antibody

Rabbit IgG

This antibody was obtained by immunization of OAS2 recombinant protein (Accession Number: NM_002535). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The 2-prime,5-prime oligoadenylate synthetases (OASs), such as OAS2, are interferon-induced proteins characterized by their capacity to catalyze the synthesis of 2-prime,5-prime oligomers of adenosine (2-5As). OAS2 is also named as p69 OAS / p71 OAS. It has 3 isoforms(71/69/20 kDa) produced by alternative splicing. The OAS2 isozymes are 69–71 kDa and form dimers(PMID:17765707). Glycosylation is essential for its activity(PMID:9880569). Constitutive expression of the 69-kDa form of the OAS2 protein in human cells inhibited the replication of encephalomyocarditis virus (EMCV) but not that of VSV, Sendai virus, or reovirus(PMID:16501108). This antibody recognizes isoform p71 and isoform p69 of OAS2.