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Product Name
OAS1 antibody
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Description
OAS1 Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue. Positive WB detected in HeLa cells, mouse brain tissue. Observed molecular weight by Western-blot: 48 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
(2 5)oligo(A) synthase 1 antibody; 2 5 oligoadenylate synthase 1 antibody; 2 5A synthase 1 antibody; E18/E16 antibody; IFI 4 antibody; OAS1 antibody; OIAS antibody; OIASI antibody; p46/p42 OAS antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of OAS1 recombinant protein (Accession Number: NM_002534). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:113458(OAS1 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human liver using Catalog No:113458(OAS1 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver using Catalog No:113458(OAS1 antibody) at dilution of 1:100 (under 40x lens)
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Background
The 2-prime,5-prime oligoadenylate synthetases (OASs), such as OAS1, are interferon-induced proteins characterized by their capacity to catalyze the synthesis of 2-prime,5-prime oligomers of adenosine (2-5As). OAS1 (type I enzymes) have molecular weights of 42, 44, 46, and 48 kDa, form tetramers, and contain a single consensus sequence(PMID:12590567). OAS1 is a strong candidate for determining susceptibility or resistance to viral infections(PMID:15732009).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"