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Product Name
Nurr1/NR4A2 antibody
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Description
Nurr1/NR4A2 Rabbit Polyclonal antibody. Positive IHC detected in human gliomas tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
HZF 3 antibody; NOT antibody; NR4A2 antibody; NURR1 antibody; Nurr1/NR4A2 antibody; Orphan nuclear receptor NURR1 antibody; RNR1 antibody; TINUR antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Nurr1/NR4A2 recombinant protein (Accession Number: XM_047444551). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human gliomas using Catalog No:113446(NR4A2 antibody) at dilution of 1:50 (under 10x lens)
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Background
NR4A2 belongs to the orphan nuclear receptor (NR) family referred to as NR4A family, which have been implicated in cell cycle regulation, apoptosis, inflammation, metabolism and more recently in carcinogenesis [PMID:22583411]. NR4A2 also has a role in the expression of several proteins that are necessary for the synthesis and regulation of dopamine (DA), such as tyrosine hidroxilase, dopamine transporter, vesicular monoamine transporter 2, and cRET [PMID:22294735]. Act as a transcriptional regulator, NR4A2 is essential for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons [PMID: 17184956].
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References
- Albino D, Scaruffi P, Moretti S. Identification of low intratumoral gene expression heterogeneity in neuroblastic tumors by genome-wide expression analysis and game theory. Cancer. 113(6):1412-22. 2008.
- Duan X, Zohaib A, Li Y. miR-206 modulates lipopolysaccharide-mediated inflammatory cytokine production in human astrocytes. Cellular signalling. 27(1):61-8. 2015.
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