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NRF1/nuclear respiratory factor 1 antibody

Cat.#: 113276

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Product Information

  • Product Name
    NRF1/nuclear respiratory factor 1 antibody
  • Documents
  • Description
    NRF1/nuclear respiratory factor 1 Rabbit Polyclonal antibody. Positive IP detected in mouse skeletal muscle tissue. Positive WB detected in mouse skeletal muscle tissue, human lung tissue. Observed molecular weight by Western-blot: 67 kDa
  • Tested applications
    ELISA, WB, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    ALPHA PAL antibody; NRF 1 antibody; NRF1 antibody; NRF1/nuclear respiratory factor 1 antibody; nuclear respiratory factor 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of NRF1/nuclear respiratory factor 1 recombinant protein (Accession Number: NM_001293163). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:200-1:1000

  • Validations

    mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with Catalog No:113276(NRF1 antibody) at dilution of 1:400

    mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with Catalog No:113276(NRF1 antibody) at dilution of 1:400

    IP Result of anti-NRF1 (IP:Catalog No:113276, 4ug; Detection:Catalog No:113276 1:300) with mouse skeletal muscle tissue lysate 3000ug.

    IP Result of anti-NRF1 (IP:Catalog No:113276, 4ug; Detection:Catalog No:113276 1:300) with mouse skeletal muscle tissue lysate 3000ug.

  • Background
    NRF1, also named as Alpha-pal and NRF-1, belongs to the NRF1/Ewg family. It is a transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. NRF1 is implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. It plays a critical role in regulating the expression of many antioxidant response element (ARE)-dependent genes.
  • References
    • Schultz MA, Hagan SS, Datta A. Nrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cells. PloS one. 9(1):e87204. 2014.
    • Lowndes SA, Sheldon HV, Cai S, Taylor JM, Harris AL. Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms. Microvascular research. 77(3):314-26. 2009.
    • Yu H, Wark L, Ji H. Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice. Molecular nutrition & food research. 57(7):1158-69. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"