NR2B antibody

Cat.#: 113234

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Product Information

  • Product Name
    NR2B antibody
  • Documents
  • Description
    NR2B Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue. Positive IF detected in SH-SY5Y cells. Observed molecular weight by Western-blot: 166kd
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    GRIN2B antibody; hNR3 antibody; NMDAR2B antibody; NR2B antibody; NR3 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_000834). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

    IF: 1:10-1:100

  • Validations

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113234(GRIN2B antibody) at dilution of 1:400

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113234(GRIN2B antibody) at dilution of 1:400

    Immunofluorescent analysis of SH-SY5Y cells using Catalog No:113234(GRIN2B Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of SH-SY5Y cells using Catalog No:113234(GRIN2B Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    GRIN2B, also named as NMDAR2B, NR3 and NR2B, belongs to the glutamate-gated ion channel (TC 1.A.10) family. GRIN2B is NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. It is mediated by glycine. The antibody recognizes the C-term of GRIN2B.
  • References
    • Geng D, Kang L, Su Y. Protective effects of EphB2 on Aβ1-42 oligomer-induced neurotoxicity and synaptic NMDA receptor signaling in hippocampal neurons. Neurochemistry international. 63(4):283-90. 2013.
    • Deng L, Li G, Rao B, Li H. Central nervous system-specific knockout of Brg1 causes growth retardation and neuronal degeneration. Brain research. 1622:186-95. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"