-
Product Name
NR1H2 antibody
- Documents
-
Description
NR1H2 Rabbit Polyclonal antibody. Positive WB detected in human liver tissue, mouse liver tissue. Observed molecular weight by Western-blot: 50 kDa, 40 kDa
-
Tested applications
ELISA, WB
-
Species reactivity
Human, Mouse; other species not tested.
-
Alternative names
Liver X receptor beta antibody; LXR b antibody; LXRB antibody; NER antibody; NER I antibody; NR1H2 antibody; Nuclear receptor NER antibody; Oxysterols receptor LXR beta antibody; RIP15 antibody; UNR antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of NR1H2 recombinant protein (Accession Number: NM_007121). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:2000
-
Validations
human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:113231(NR1H2 antibody) at dilution of 1:500
-
Background
NR1H2, also known as LXRB, is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. It preferentially bind to double-stranded oligonucleotide direct repeats, which have the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). It involves in the regulation of cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
-
References
- Wang Q, Ma X, Chen Y. Identification of interferon-γ as a new molecular target of liver X receptor. The Biochemical journal. 459(2):345-54. 2014.
- Ma X, Wang Q, Liu Y. Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production. International journal of cancer. 136(4):771-83. 2015.
- He Y, Zhang L, Li Z. RIP140 triggers foam-cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor. FEBS letters. 589(4):455-60. 2015.
- Liu M, Chen Y, Zhang L. Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II. The Journal of biological chemistry. 290(23):14418-29. 2015.
- Zhang L, Jiang M, Shui Y. DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism. Biochimica et biophysica acta. 1831(6):1134-45. 2013.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"